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Angerrule5

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Ld be useful for much better knowledge of the mechanism of WTLd be helpful for improved understanding of the system of WT1-mediated leukemogenesis and tumorigenesis. During this analyze, Ex4a(+)WT1 isoform inhibited the transcriptional activation of Bcl-xL and Bcl-2 genes by significant WT1 isoform [17AA(+)KTS(-)WT1]. It was noted that significant WT1 isoform exerts transcriptional action as
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The current examine confirmed which the WT1 gene was alternatively spliced at Ex4a to produce isoforms with opposing roles in apoptosis, anti-apoptotic isoforms (significant WT1 isoforms) and pro-apoptotic isoform (truncated Ex4a(+)WT1 isoform). A number of other genes involved in apoptosis, these kinds of as p53 [39], Survivin [40], Fas [41], and caspase-9 [42] are recognised to make isoforms wit