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The suppression of important WT1 isoform-mediated transcriptional activation by Ex4a(+) WT1 is likely to be extended to other direct transcriptional targets at the same time as Bcl-xL and Bcl-2. Since various other genes accountable for anti-apoptosis this kind of as BFL-1 and c-myc have already been also discovered as direct transcriptional targets of main WT1 isoforms [16, 17], Ex4a(+)WT1-induce

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