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In conclusion, expression regarding Foxa2-T156A, K259Q, and T156A-K259Q mutants inside the liver of?db/db mice?improved hyperglycemia, hepatic steatosis, as well as insulin shots level of sensitivity, while wild-type Foxa2, K259R, as well as T156A-K259R mutants didn't have any influence on these variables. Foxa2 may be a essential regulator of the transcriptional system with the hard working liver

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