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Hence, it was affordable that the mechanism of inhibition of big WT1 isoform-mediated transcriptional activation of Bcl-xL and Bcl-2 by Ex4a(+)WT1 isoform could possibly be level of competition with key WT1 isoform for interacting along with the transcriptional co-activators besides WT1 itself, resulting within the abrogation of major WT1 isoform-mediated transcriptional action in leukemia cells.

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