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Our finding that Chd5 inhibits term in the oncogenic PcG health proteins Bmi1 shows that Chd5 inhibits PcG-mediated chromatin mechanics at multiple levels. In summary, the project defines a certain histone tag which is?bound by Chd5 and it is necessary for its ability to control transcriptional flows, inhibit proliferation, encourage distinction, and?efficiently suppress tumorigenesis in?vivo. The